资源类型

期刊论文 222

会议信息 1

年份

2023 16

2022 25

2021 27

2020 10

2019 11

2018 9

2017 15

2016 16

2015 7

2014 10

2013 4

2012 6

2011 9

2010 15

2009 7

2008 10

2007 13

2006 1

2005 3

2004 2

展开 ︾

关键词

波粒二象性 3

粒子群优化 3

烟颗粒 2

粒子群优化算法 2

2型糖尿病 1

COVID-19 1

Fe、Co、Ru 碳化物 1

Hilare 机器人 1

Pickering乳液 1

SPH 1

SWAT-WF模块 1

上限法 1

二维纳米颗粒 1

二维非线性动力学 1

亚细胞定位 1

人脑功能磁共振 1

代表性体积元 1

优化调度 1

体液免疫应答 1

展开 ︾

检索范围：

排序： 展示方式：

Investigation on sampling artifacts of particle associated PAHs using ozone denuder systems

Kai LIU, Fengkui DUAN, Kebin HE, Yongliang MA, Yuan CHENG

《环境科学与工程前沿（英文）》 2014年 第8卷 第2期   页码 284-292 doi: 10.1007/s11783-013-0555-7

摘要： Polycyclic aromatic hydrocarbons (PAHs) are complex organic compounds which are identified as significant carcinogenic to human health. PAHs (mainly in particle phase) are susceptible to atmospheric oxidant gases, especially ozone, nitrogen oxides (NO ), hydroxyl radical (OH), and could be degraded on filters during sampling process, leading to an underestimation of ambient PAH concentrations. The goal of this work was to investigate particle associated PAHs sampling artifacts caused by ozone in summer of Beijing. Comparative sampling systems were operated simultaneously during the whole campaign, one with activated carbon ozone denuder, the other being set as conventional sampling system. Activated carbon denuder was testified to be highly efficient to eliminate ozone from air stream. In general, nine particle-bound PAHs observed from conventional sampler were all lower than those from ozone denuder system. The total PAHs (particle phase) concentration was averagely underestimated by 35.9% in conventional sampling procedure. Benzo[a]pyrene (BaP) had the highest percentage of mass loss. Ambient temperature was founded to have influences on PAHs sampling artifacts. High temperature can increase loss of particle associated PAHs during sampling.

关键词： particle associated polycyclic aromatic hydrocarbons (PAHs)     ozone     denuder     sampling artifacts    

HTML PDF 收藏

Particle-bound polycyclic aromatic hydrocarbons in typical urban of Yunnan-Guizhou Plateau: Characterization

《环境科学与工程前沿（英文）》 2022年 第16卷 第9期 doi: 10.1007/s11783-022-1535-6

摘要：

• The sampling was conducted in city on the Yunnan-Guizhou Plateau for one year.

关键词： Particle-associated PAHs     Fine particle     Source appointment     Group analysis     Risk assessment     Biomass burning    

HTML PDF 收藏

Enrichment and transfer of polycyclic aromatic hydrocarbons (PAHs) through dust aerosol generation from

《环境科学与工程前沿（英文）》 2023年 第17卷 第1期 doi: 10.1007/s11783-023-1610-7

摘要：

● Compositional patterns of PAHs in dust aerosol vary from soil during dust generation.

关键词： Dust aerosols     Enrichment factors (EFs)     Polycyclic aromatic hydrocarbons (PAHs)    

HTML PDF 收藏

The transformation of PAHs in the sewage sludge incineration treatment

Hui ZHANG,Le XU,Yifei ZHANG,Mengchan JIANG

《环境科学与工程前沿（英文）》 2016年 第10卷 第2期   页码 336-340 doi: 10.1007/s11783-014-0766-6

摘要： The release of pollutants from sewage sludge in the treatment process is a worldwide tricky problem in the field of sludge treatment. In this paper, the release and reaction between monomers of polycyclic aromatic hydrocarbons (PAHs) in the sewage sludge incineration treatment were studied based on simulated experiments. The result indicates that the transformation may occurre between monomers of PAHs during their release in the treatment. Over 90% of total PAHs in sewage sludge are released at the the temperature of 300°C–750°C. The possible transformation of Naphthalene to indeno(1, 2, 3-cd)pyrene was related to the temperature of the treatment system. Here, we showed that the output rate of transformation reactions for indeno(1, 2, 3-cd)pyrene is 94% at 300°C. These findings, by identifying corresponding treatment conditions as well as techniques, can help to understand the reactions and control real outputs of PAHs in the treatment process.

关键词： release of monomers     transformation of monomers     PAHs     sewage sludge     incineration treatment    

HTML PDF 收藏

Multiphase redistribution differences of polycyclic aromatic hydrocarbons (PAHs) between two successive

Rufeng LI,Chenghong FENG,Dongxin WANG,Baohua LI,Zhenyao SHEN

《环境科学与工程前沿（英文）》 2016年 第10卷 第2期   页码 381-389 doi: 10.1007/s11783-015-0817-7

摘要： Successive sediment suspensions often happen in estuary, yet little research has probed into the difference in the release behaviors of organic compounds among different suspensions. This study took polycyclic aromatic hydrocarbons (PAHs) as typical organic contaminants and investigated the release behaviors between two successive suspensions with a particle entrainment simulator (PES). Results showed that successive sediment suspensions lowered the concentration of dissolved PAHs in the overlying water via facilitating the re-adsorption of dissolved PAHs onto the suspended particles. Fast-release and slow-release periods of PAHs were successively observed in the both suspensions. The concentration changes of dissolved PAHs in the second suspension were generally similar with but hysteretic to those in the first suspension. More vigorous desorption and re-absorption of PAHs were induced in the second suspension. Successive sediment suspensions obviously decreased the concentrations of mineral composition and organic matters in the overlying water, which significantly affects multiphase distribution of PAHs.

关键词： sediment suspension     PAHs     multiphase distribution     distribution coefficients    

HTML PDF 收藏

Biologic risk and source diagnose of 16 PAHs from Haihe River Basin, China

Qiuying CHEN,Jingling LIU,Feng LIU,Binbin WANG,Zhiguo CAO

《环境科学与工程前沿（英文）》 2016年 第10卷 第1期   页码 46-52 doi: 10.1007/s11783-014-0717-2

摘要： Surface sediments of rivers can exhibit spatial and temporal variations in contaminant concentrations that may significantly affect risk evaluations. As to pollution control and remediation of watershed, large-scale and further background data on PAHs in China were required urgently. Spatial distribution and compositional characteristics of 16 polycyclic aromatic hydrocarbons (PAHs) in surface sediments from Haihe River Basin were investigated. A method based on effects range (ER) was used to assess ecosystem risk of ∑PAHs (the total of 16 PAH) sensitively and accurately. The results indicated that ∑PAHs content levels ranged from 257 to 16901 μg·kg dry weight. The lower rings predominated in the samples, and 2-, 3-, 4-, 5- and 6-ring PAHs accounted for 12%, 21%, 30%, 30%, and 7% respectively in total PAHs. The ratio of Fl / (Fl+ Py) uniformly distributed in the interval 0.20–0.80, indicating that it may be affected by petroleum origin, oil combustion, biomass and coal combustion jointly. ∑PAHs in Cetian (S6), Dongwushi (S19), Handan (S20), Aixinzhuang (S21) and Tianjin (S37) exceeded effects range low (ERL), in which biologic effects were in a medium level with an adverse effect on biologic organisms. Thus, it is necessary to strengthen the PAHs monitoring and research of the Haihe River Basin.

关键词： polycyclic aromatic hydrocarbons (PAHs)     biological effects     sediment     Haihe River    

HTML PDF 收藏

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

《医学前沿（英文）》 2008年 第2卷 第4期   页码 323-331 doi: 10.1007/s11684-008-0062-6

摘要： Hypertension is characterized by vascular smooth muscle constriction and vascular remodeling involving cell migration, hypertrophy and growth. Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has been shown to be a critical cellular component that regulates various smooth muscle functions. In this review, the molecular structure and protein interactions of the CAS family members are summarized. Evidence for the role of CAS in the regulation of vascular smooth muscle contractility is presented. Contraction stimulation induces CAS phosphorylation on Tyr-410 in arterial smooth muscle, creating the binding site for the Src homology (SH) 2/SH3 protein CrkII, which activates neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin assembly and force development. The functions of CAS in cell migration, hypertrophy and growth are also summarized. Abelson tyrosine kinase (Abl), c-Src, focal adhesion kinase (FAK), proline-rich tyrosine kinase 2 (PYK2), protein tyrosine phosphatase-proline, glutamate, serine and threonine sequence protein (PTP-PEST) and SHP-2 have been documented to coordinate the phosphorylation and dephosphorylation of CAS. The downstream signaling partners of CAS in the context of cell motility, hypertrophy, survival and growth are also discussed. These new findings establish the important role of CAS in the modulation of vascular smooth muscle functions. Furthermore, the upstream regulators of CAS may be new biologic targets for the development of more effective and specific treatment of cardiovascular diseases such as hypertension.

关键词： Contraction stimulation     phosphatase-proline     molecular structure     discovered     hypertension    

HTML PDF 收藏

Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

《医学前沿（英文）》 2022年 第16卷 第3期   页码 459-466 doi: 10.1007/s11684-021-0841-x

摘要： Whether Fanconi anemia (FA) heterozygotes are predisposed to bone marrow failure and hematologic neoplasm is a crucial but unsettled issue in cancer prevention and family consulting. We retrospectively analyzed rare possibly significant variations (PSVs) in the five most obligated FA genes, BRCA2, FANCA, FANCC, FANCD2, and FANCG, in 788 patients with aplastic anemia (AA) and hematologic malignancy. Sixty-eight variants were identified in 66 patients (8.38%). FANCA was the most frequently mutated gene (n = 29), followed by BRCA2 (n = 20). Compared with that of the ExAC East Asian dataset, the overall frequency of rare PSVs was higher in our cohort (P = 0.016). BRCA2 PSVs showed higher frequency in acute lymphocytic leukemia (P = 0.038), and FANCA PSVs were significantly enriched in AA and AML subgroups (P = 0.020; P = 0.008). FA-PSV-positive MDS/AML patients had a higher tumor mutation burden, higher rate of cytogenetic abnormalities, less epigenetic regulation, and fewer spliceosome gene mutations than those of FA-PSV-negative MDS/AML patients (P = 0.024, P = 0.029, P = 0.024, and P = 0.013). The overall PSV enrichment in our cohort suggests that heterozygous mutations of FA genes contribute to hematopoietic failure and leukemogenesis.

关键词： Fanconi anemia     aplastic anemia     hematologic malignancy     germline predisposition    

HTML PDF 收藏

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

《医学前沿（英文）》 2022年 第16卷 第5期   页码 714-722 doi: 10.1007/s11684-021-0888-8

摘要： A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposed. We aim to examine the associations of MAFLD, particularly its discordance from non-alcoholic fatty liver disease (NAFLD), with the progression of elevated brachial-ankle pulse wave velocity (baPWV) and albuminuria in a community-based study sample in Shanghai, China. After 4.3 years of follow-up, 778 participants developed elevated baPWV and 499 developed albuminuria. In comparison with the non-MAFLD group, the multivariable adjusted odds ratio (OR) of MAFLD group for new-onset elevated baPWV was 1.25 (95% confidence interval (CI) 1.01–1.55) and 1.35 (95% CI 1.07–1.70) for albuminuria. Participants without NAFLD but diagnosed according to MAFLD definition were associated with higher risk of incident albuminuria (OR 1.77; 95% CI 1.07–2.94). Patients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higher risk of elevated baPWV or albuminuria. In conclusion, MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body mass index, waist circumference, and hip circumference. Individuals without NAFLD but diagnosed as MAFLD had high risk of albuminuria, supporting that MAFLD criteria would be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver patients.

关键词： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score     brachial-ankle pulse wave velocity     albuminuria    

HTML PDF 收藏

Transparent exopolymer particles (TEPs)-associated protobiofilm: A neglected contributor to biofouling

《环境科学与工程前沿（英文）》 2021年 第15卷 第4期 doi: 10.1007/s11783-020-1361-7

摘要：

• Bacteria could easily and quickly attached onto TEP to form protobiofilms.

关键词： Transparent exopolymer particles (TEPs)     TEP-protobiofilm     Bacteria attachment     Biofouling of membrane    

HTML PDF 收藏

Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery

null

《医学前沿（英文）》 2017年 第11卷 第2期   页码 239-246 doi: 10.1007/s11684-017-0509-8

摘要：

Patients undergoing major oncological surgery for head and neck cancer (SHNC) have a particularly high risk of nosocomial infections. We aimed to identify risk factors for ventilator-associated pneumonia (VAP) in patients undergoing SHNC. The study included 465 patients who underwent SHNC between June 2011 and June 2014. The rate of VAP, risk factors for VAP, and biological aspects of VAP were retrospectively evaluated. The incidence of VAP was 19.6% (n=95) in patients who required more than 48 h of mechanical ventilation. Staphylococcus (37.7%), Enterobacteriaceae (32.1%), Pseudomonas(20.8%), and Haemophilus (16.9%) were the major bacterial species that caused VAP. The independent risk factors for VAP were advanced age, current smoking status, chronic obstructive pulmonary disease, and a higher simplified acute physiology score system II upon admission. Tracheostomy was an independent protective factor for VAP. The median length of stay in the ICU for patients who did or did not develop VAP was 8.0 and 6.5 days, respectively (P=0.006). Mortality among patients who did or did not develop VAP was 16.8% and 8.4%, respectively (P<0.001). The potential economic impact of VAP was high because of the significantly extended duration of ventilation. A predictive regression model was developed with a sensitivity of 95.3% and a specificity of 69.4%. VAP is common in patients who are undergoing SHNC and who require more than 48 h of mechanical ventilation. Therefore, innovative preventive measures should be developed and applied in this high-risk population.

关键词： ventilator-associated pneumonia (VAP)     pneumonia     risk factors     surgery for head and neck cancer (SHNC)    

HTML PDF 收藏

The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid

null

《医学前沿（英文）》 2017年 第11卷 第3期   页码 359-364 doi: 10.1007/s11684-017-0528-5

摘要：

Thyroid-associated orbitopathy (TAO) is an inflammatory autoimmune disorder. The most serious complication of TAO is dysthyroid optic neuropathy (DON), which can lead to permanent vision loss because of volume expansion in the orbital apex. Orbital radiation therapy (ORT) is an anti-inflammatory treatment used in the treatment of active TAO. Clinical studies support radiotherapy as having a modest effect on DON, and early radiotherapy may protect against disease progression to DON. Current studies suggest that radiotherapy is generally safe. However, risks still exist in some cases. The possible effects of radiotherapy on TAO, especially complicated with DON, are reviewed. The effects of radiotherapy on DON are not completely known, and evidence from standardized, prospective, and multicenter clinical trials is still lacking.

关键词： thyroid-associated orbitopathy     dysthyroid optic neuropathy     orbital radiation therapy    

HTML PDF 收藏

Catalyst particle shapes and pore structure engineering for hydrodesulfurization and hydrodenitrogenation

《化学科学与工程前沿（英文）》 2022年 第16卷 第6期   页码 897-908 doi: 10.1007/s11705-021-2127-x

摘要： Catalyst particle shapes and pore structure engineering are crucial for alleviating internal diffusion limitations in the hydrodesulfurization (HDS)/hydrodenitrogenation (HDN) of gas oil. The effects of catalyst particle shapes (sphere, cylinder, trilobe, and tetralobe) and pore structures (pore diameter and porosity) on HDS/HDN performance at the particle scale are investigated via mathematical modeling. The relationship between particle shape and effectiveness factor is first established, and the specific surface areas of different catalyst particles show a positive correlation with the average HDS/HDN reaction rates. The catalyst particle shapes primarily alter the average HDS/HDN reaction rate to adjust the HDS/HDN effectiveness factor. An optimal average HDS/HDN reaction rate exists as the catalyst pore diameter and porosity increase, and this optimum value indicates a tradeoff between diffusion and reaction. In contrast to catalyst particle shapes, the catalyst pore diameter and the porosity of catalyst particles primarily alter the surface HDS/HDN reaction rate to adjust the HDS/HDN effectiveness factor. This study provides insights into the engineering of catalyst particle shapes and pore structures for improving HDS/HDN catalyst particle efficiency.

关键词： hydrodesulfurization     hydrodenitrogenation     particle shape     pore structure    

HTML PDF 收藏

A novel light fluctuation spectrum method for in-line particle sizing

Shouxuan QIN, Xiaoshu CAI, Li MA

《能源前沿（英文）》 2012年 第6卷 第1期   页码 89-97 doi: 10.1007/s11708-012-0176-z

摘要： This paper discusses two problems in in-line particle sizing when using light fluctuation method. First, by retrieving the ratio of particle concentrations at different time, the intensity of incident light is obtained. There exists narrow error between the calculated and pre-detected value of the intensity of incident light. Secondly, by combining spectrum analysis with Gregory’s theory, a multi-sub-size zone model is proposed, with which the relationship between the distribution of turbidity and the particle size distribution (PSD) can be established, and an algorithm developed to determine the distribution of turbidity. Experiments conducted in the laboratory indicate that the measured size distribution of pulverized coal conforms well with the imaging result.

关键词： in-line measurement     particle size distribution (PSD)     incident light intensity     particle concentration     light fluctuation    

HTML PDF 收藏

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

《医学前沿（英文）》 2018年 第12卷 第6期   页码 667-677 doi: 10.1007/s11684-017-0583-y

摘要： Platelets have long been known to play critical roles in hemostasis by clumping and clotting blood vessel injuries. Recent experimental evidence strongly indicates that platelets can also interact with tumor cells by direct binding or secreting cytokines. For example, platelets have been shown to protect circulating cancer cells in blood circulation and to promote tumor metastasis. In-depth understanding of the role of platelets in cancer progression and metastasis provides promising approaches for platelet biomimetic drug delivery systems and functional platelet-targeting strategies for effective cancer treatment. This review highlights recent progresses in platelet membrane-based drug delivery and unique strategies that target tumor-associated platelets for cancer therapy. The paper also discusses future development opportunities and challenges encountered for clinical translation.

关键词： platelet-mimicking delivery systems     tumor-associated platelets     cancer therapy     EPR effect    

HTML PDF 收藏

标题 作者 时间 类型 操作

Investigation on sampling artifacts of particle associated PAHs using ozone denuder systems

Kai LIU, Fengkui DUAN, Kebin HE, Yongliang MA, Yuan CHENG

期刊论文

Particle-bound polycyclic aromatic hydrocarbons in typical urban of Yunnan-Guizhou Plateau: Characterization

期刊论文

Enrichment and transfer of polycyclic aromatic hydrocarbons (PAHs) through dust aerosol generation from

期刊论文

The transformation of PAHs in the sewage sludge incineration treatment

Hui ZHANG,Le XU,Yifei ZHANG,Mengchan JIANG

期刊论文

Multiphase redistribution differences of polycyclic aromatic hydrocarbons (PAHs) between two successive

Rufeng LI,Chenghong FENG,Dongxin WANG,Baohua LI,Zhenyao SHEN

期刊论文

Biologic risk and source diagnose of 16 PAHs from Haihe River Basin, China

Qiuying CHEN,Jingling LIU,Feng LIU,Binbin WANG,Zhiguo CAO

期刊论文

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

期刊论文

Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

期刊论文

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

期刊论文

Transparent exopolymer particles (TEPs)-associated protobiofilm: A neglected contributor to biofouling

期刊论文

Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery

null

期刊论文

The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid

null

期刊论文

Catalyst particle shapes and pore structure engineering for hydrodesulfurization and hydrodenitrogenation

期刊论文

A novel light fluctuation spectrum method for in-line particle sizing

Shouxuan QIN, Xiaoshu CAI, Li MA

期刊论文

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

期刊论文